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microglia    
小神经胶质; 格子细胞

小神经胶质; 格子细胞


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  • Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
    Yet, SORL1 gets plenty busy in microglia, as well, albeit on a different set of tasks, namely, supporting the lysosome Previously, Young and colleagues found that while SORL1-deficient hiPSC-derived neurons were choked with swollen endosomes, human microglial-like cells (hMGLs) had bulging lysosomes instead
  • After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods
    Microglia also took on distinct signatures depending on the extent of amyloid clearance in their neighborhood For example, in cases of extensive plaque clearance, the cells upregulated myristoylated alanine-rich C kinase substrate, a protein involved in cell motility and phagocytosis, and fibroblast growth factor receptor 3 in addition to ApoE
  • With Age, Synaptic Protein Turnover Stalls, Choking Microglia
    Second, isolation of microglia showed an accumulation of neuron-derived, metabolically labeled proteins within microglia in aged animals Notably, there was substantial overlap among proteins whose degradation slows with age, those that become insoluble, and those that are transferred to microglia
  • ACE Supercharges Microglia to Shrink Plaques | ALZFORUM
    Mouse microglia got a genetic tune-up On 9 June in Nature Aging, researchers led by Warren G Tourtellotte at Cedars-Sinai Medical Center in Los Angeles reported that expressing human angiotensin-converting enzyme (ACE) in mouse microglia boosts their uptake of Aβ, clearing out plaques in a model
  • Releasing the Brakes on SYK Kinase Fires Up Microglia
    PTP1B knockout microglia made more ATP than did PTP1B+ cells, and they better amped up glycolysis after being stimulated with Aβ oligomers Conversely, treating PTP1B knockout microglia with a SYK inhibitor depressed their metabolism and phagocytic abilities to the level of PTP1B+ cells, establishing SYK as the key mechanism
  • C5aR1+ microglia exacerbate neuroinflammation and cerebral edema in . . .
    Together, these findings establish C5aR1-positive microglia as a central driver of neuroinflammation-induced cerebral edema and highlight microglial C5aR1 as a promising therapeutic target for acute brain injury
  • Lipid-Laden, Sluggish Microglia? Blame Aβ. - ALZFORUM
    Microglia and macrophages make lipid droplets when stressed by inflammation Scientists believe the lipids sustain the cells’ metabolic need, enabling them to respond to threats (van Dierendonck et al , 2022; reviewed by Olzmann and Carvalho, 2019) Wyss-Coray previously described lipid-droplet accumulating microglia (LDAMs) that spewed pro-inflammatory cytokines in the hippocampi of old
  • Lymphoid gene expression supports neuroprotective microglia function . . .
    An open question is whether CD28 + PU 1 low microglia are related to T cell interaction, recruitment and or activation, but collectively, both studies endorse the relevance of investigating the plasticity of plaque-associated microglia, and they suggest that known adaptive-immune checkpoints control a neuroprotective microglial state
  • AD Gene PICALM Hampers Phagocytosis, Promotes Lipid Droplets in Microglia
    Overexpressing PICALM soothed microglia, dropping lipid droplets back to normal levels Priyanka Narayan at the National Institutes of Health in Bethesda, Maryland, was struck by how much these PICALM phenotypes resemble APOE4 biology, which also involves dysregulated lipids, lysosomes, and phagocytosis, along with accumulation of lipid droplets
  • Apolipoprotein E aggregation in microglia initiates Alzheimers disease . . .
    ApoE and Aβ Click in Lysosomes, Seeding Plaque Kaji et al propose that fibrillar ApoE—likely forming in microglia lysosomes after internalization and delipidation of the lipid carriers—promotes aggregation of Aβ The authors preaggregated HFIP Aβ by incubating a solution in PBS for 48 hours at 37°C, then fed this to microglial cell





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