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digitoxin    
毛地黄毒甙; 洋地黄毒甙

毛地黄毒□; 洋地黄毒□

digitoxin
n 1: digitalis preparation used to treat congestive heart
failure or cardiac arrhythmia

digitoxin \dig`i*tox"in\ (d[i^]j`[i^]*t[o^]k"s[i^]n), n. (Chem.)
A steroid glycoside, one of the cardiotonic chemical
substances which is extracted from the foxglove. It is a
white, crystalline substance ({C41H64O13}), and is a
3-substituted triglucoside of a steroid, related structurally
to digitalin and digoxin. It is used as a cardiotonic for
treatment of certain heart conditions, such as congestive
heart failure. Chemically it is

(3[beta],5[beta])-3-[(O-2,6-Dideoxy-[beta]-D-ribo-hexopyranosyl-(1[rarr]4)-O-2,6-dideoxy-[beta]-D-ribo-hexopyranosyl-(1[rarr]4)-2,
6-dideoxy-[beta]-D-ribo-hexopyranosyl)oxy]-14-hydroxy-card-20(22)-enolide.
The related compounds {digitalin} and {digoxin} are also
extracted from the foxglove ({Digitalis lanata} and
{Digitalis purpurea}). The class of steroid glycosides having
cardiotonic properties are refered to as the cardiac
glycoside group. --MI11
[PJC]


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  • Digitoxin - Wikipedia
    Digitoxin is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia It is a phytosteroid and is similar in structure and effects to digoxin, though the effects are longer-lasting
  • Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction
    Treatment with digitoxin led to a lower combined risk of death from any cause or hospital admission for worsening heart failure than placebo among patients with heart failure and reduced ejection
  • Digitoxin: Uses, Interactions, Mechanism of Action | DrugBank
    Digitoxin is a cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure
  • Digitoxin - an overview | ScienceDirect Topics
    Digitoxin is a lipid-soluble cardiac glycoside that is used to treat congestive heart failure, arrhythmias, and heart failure It works by blocking the sodium-potassium ATPase in the plasma membrane, which leads to changes in intracellular sodium, calcium, and potassium levels
  • Digitoxin improves outcomes in advanced heart failure
    Digitoxin reduced the risk of a composite of all-cause death and hospital admission for worsening heart failure, suggesting digitoxin may represent an additional treatment to current guideline-recommended therapies, particularly where these cannot be tolerated
  • Digitoxin Cuts Risk in Well-Treated HFrEF Patients: DIGIT-HF
    Digitoxin is considered a safer cardiac glycoside than digoxin, with serum concentrations remaining stable without dose adjustments In the DIG trial, digoxin failed to reduce the risk of all-cause mortality, but treatment cut the risk of hospitalization for worsening HF
  • Simple and safe digitoxin dosing in heart failure based on data from . . .
    The present study aimed to develop a simple dosing score when starting the cardiac glycoside digitoxin in heart failure with reduced ejection fraction (HFrEF) employing first data from the randomized, double-blinded DIGIT-HF trial
  • Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction
    Treatment with digitoxin led to a lower combined risk of death from any cause or hospital admission for worsening heart failure than placebo among patients with heart failure and reduced ejection fraction who received guideline-directed medical therapy





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