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  • Pathology Outlines - HCC - scirrhous type
    Scirrhous type of hepatocellular carcinoma is a subtype of hepatocellular carcinoma (HCC) designated by the WHO with abundant fibrous stroma separating nests and trabecula of tumor cells
  • Pathology Outlines - Hepatocellular carcinoma overview
    Glypican 3: cytoplasmic; high sensitivity in poorly differentiated and scirrhous hepatocellular carcinoma but low sensitivity in well differentiated hepatocellular carcinoma (nonneoplastic liver is negative) AFP: cytoplasmic; highly specific but low sensitivity; frequently negative in well differentiated hepatocellular carcinoma
  • Pathology Outlines - WHO classification
    WHO classification of tumors of the liver and intrahepatic bile ducts Currently on 5th edition, published in 2019 Based on histologic appearance, not molecular characteristics
  • Invasive breast cancer of no special type (NST)
    Most common type of invasive breast carcinoma (75 - 80%) and an invasive carcinoma with evidence of mammary epithelial origin either by morphology or immunohistochemistry
  • Pathology Outlines - Staging-hepatocellular carcinoma
    Liver and intrahepatic bile ducts - TNM staging of hepatocellular carcinomas (AJCC 8th edition)
  • Pathology Outlines - Question Bank
    A 20 year old man with known cystic fibrosis presents with abdominal pain localized to the right lower quadrant Imaging reveals an enlarged, mucus filled appendix What is the most likely histologic finding in the appendix of this patient? Appendiceal dilation with inspissated mucus Epithelial dysplasia with fibrotic changes Hyperplasia of the lymphoid tissue Mucinous neoplasms
  • Pathology Outlines - Question Bank
    Which of the following is true regarding the scirrhous variant of hepatocellular carcinoma? Association with hypocalcemia has been described CK7 and CK19 are often negative It is associated with TSC1 TSC2 mutations There is often necrosis or hemorrhage
  • Pathology Outlines - HCC - lymphocyte rich
    Lymphocyte rich hepatocellular carcinoma is a rare subtype of hepatocellular carcinoma (HCC) designated by the WHO and characterized by a dense lymphoid infiltrate with more lymphocytes than tumor cells
  • Pathology Outlines - Ductal adenocarcinoma, NOS
    Pancreas - Ductal adenocarcinoma, NOS, invasive pancreatic epithelial neoplasm with glandular (ductal) differentiation, usually demonstrating luminal or intracellular mucin and without a substantial component of any other histological type
  • Pathology Outlines - WHO classification
    Breast - WHO classification - Tumor classification is dynamic process integrating multiple sources of recent information; based on current 5th edition, published in 2019





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