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  • Fas ligand - Wikipedia
    Fas ligand (FasL, also known as CD95L or Apo-1L) is a type-II transmembrane protein in the tumor necrosis factor (TNF) superfamily It binds to the Fas receptor (CD95) to induce apoptosis, and also activates non-apoptotic pathways such as NF-κB and MAPK FasL exists in membrane-bound and soluble forms, and is primarily expressed by cytotoxic T lymphocytes and natural killer cells It plays a critical role in immune regulation, immune privilege, cancer, autoimmunity, and transplantation
  • Fas and FasL: The Death Receptor and Its Activator
    In some forms of liver disease, for instance, over-stimulation of the Fas pathway leads to the widespread death of liver cells and progressive organ damage The pathway has also been implicated in graft-versus-host disease, where immune cells from a transplant attack the recipient’s tissues, and may contribute to cell loss in certain neurodegenerative disorders Because of its role in these processes, the Fas FasL pathway is an area of intense research for new therapies aimed at either
  • The many roles of FAS receptor signaling in the immune system
    FAS (also known as APO-1 or CD95) belongs to the subgroup of the tumor necrosis factor receptor (TNF-R) family that contain an intra-cellular ‘death domain’ and can trigger apoptosis Zhu H, Xu CJ, Yuan J Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis Cell 1998;94:491–501 doi: 10 1016 s0092-8674(00)81590-1 [Google Scholar] Lowin B, Hahne M, Mattmann C, Tschopp J Cytolytic T-cell cytotoxicity is mediated through perforin and Fas
  • The Fas signaling pathway: more than a paradigm - PubMed
    The intrinsic pathway emerges from mitochondria, whereas the extrinsic pathway is activated by the ligation of death receptors This Viewpoint introduces the basic mechanisms of the extrinsic pathway, using the example of the prototypical death receptor Fas and its role in apoptosis, but it also points out the increasingly understood importance of this receptor as a non-apoptotic signal transducer
  • (PDF) The Fas - Fas Ligand apoptotic pathway - ResearchGate
    THE APO-l (Fas CD95) cell surface receptor is a member of the nerve growth factor (NGF) tumour necrosis factor (TNF) receptor superfamily and mediates apoptosis1 -4
  • The Fas Pathway in Apoptosis - ScienceDirect
    The Fas Pathway in Apoptosis I I3 CTL \ TARGET CELL FIGURE 2 TCR-induced expression of FasL and cell-mediated cytotoxicity TCR recognition of MHC-associated peptides induces the transcription of FasL andlor increases the stability of FasL mRNA ( 1 ) Alternatively spliced mRNA leads to the surface expression (2a)or secretion (2b) of FasL Membrane-bound or soluble FasL binds to Fas o n the target cell, inducing apoptosis (3)
  • Extrinsic Pathway of Apoptosis – Definition, Mechanism, Functions . . .
    The extrinsic pathway of apoptosis is a process whereby cells initiate programmed cell death in response to external signals, such as those from neighbouring Fas ligand binding to Fas receptor results in the binding of the adapter protein FADD, whereas TNF ligand binding to TNF receptor results in the binding of the adapter protein TRADD and the recruitment of FADD and RIP Upon dimerization of the death effector domain, FADD then interacts with procaspase-8
  • The Fas Signaling Pathway: More Than a Paradigm | Science - AAAS
    The intrinsic pathway emerges from mitochondria, whereas the extrinsic pathway is activated by the ligation of death receptors This Viewpoint introduces the basic mechanisms of the extrinsic pathway, using the example of the prototypical death receptor Fas and its role in apoptosis, but it also points out the increasingly understood importance of this receptor as a non-apoptotic signal transducer





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