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  • Syncytium - Wikipedia
    A syncytium ( sɪnˈsɪʃiəm ; pl : syncytia; from Greek: σύν syn "together" and κύτος kytos "box, i e cell") or symplasm is a multinucleate cell that can result from multiple cell fusions of uninuclear cells (i e , cells with a single nucleus), in contrast to a coenocyte, which can result from multiple nuclear divisions without accompanying cyto
  • The role of syncytia during viral infections - PubMed
    RSV is characterized by syncytia, which are multinuclear cells created by cells that have fused together We use a mathematical model to study how different assumptions about the viral production and lifespan of syncytia change the resulting infection time course
  • Syncytia formation during SARS-CoV-2 lung infection: a . . . - Nature
    Syncytia are evolutionarily conserved cellular structures form by the multiple cell fusions of uninuclear cells In mammals, the best example of physiological syncytia is muscle fibers, which
  • Syncytia Formation and Immune Evasion in Viral Infections
    Syncytia formation allows viruses to spread directly between cells, bypassing extracellular spaces where they might be targeted by antibodies We’ll explore the mechanisms behind syncytia formation and its implications for immune evasion in viral infections
  • Syncytia formation by SARS‐CoV‐2‐infected cells - PMC
    Severe cases of COVID‐19 are associated with extensive lung damage and the presence of infected multinucleated syncytial pneumocytes The viral and cellular mechanisms regulating the formation of these syncytia are not well understood Here, we show
  • Syncytia: Origin, Structure, and Functions | SpringerLink
    The book offers a fresh outlook on syncytia's role in various processes: embryogenesis, organogenesis, adaptation, host defense, and development of specialized tissues It highlights the importance of syncytia under physiological and pathological conditions
  • The role of syncytia during viral infections - ScienceDirect
    Respiratory syncytial virus (RSV) is a common, contagious infection of the lungs and the respiratory tract RSV is characterized by syncytia, which are multinuclear cells created by cells that have fused together
  • Syncytia: From a Historical Resumption to Epigenetic Advances
    Syncytia, which are multinucleated cell structures formed by cell fusion, exemplify the capacity of epigenetic mechanisms to influence cellular outcomes in dynamic environments
  • Syncytia Formation in Viral Infections and Host Cell Impact
    Syncytia formation impacts the dynamics of viral infections by altering the way viruses spread and persist within host tissues When host cells merge into a single multinucleated structure, it creates an environment where viruses can replicate more efficiently
  • The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and . . .
    Syncytia are formed when individual cells fuse SARS-CoV-2 induces syncytia when the viral spike (S) protein on the surface of an infected cell interacts with receptors on neighboring cells Syncytia may potentially contribute to pathology by facilitating viral dissemination, cytopathicity, immune evasion, and inflammatory response
  • High-throughput screening of genetic and cellular drivers of syncytium . . .
    Mapping mutations and discovering cellular determinants that cause the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to induce infected cells to form syncytia
  • Virus-Induced Syncytia: Fusion Protein Culprits | MedShun
    Syncytia are formed when multiple cells fuse together This can occur during reproduction, organ and tissue growth, cancer metastasis, immune response, and infection Certain viruses can cause syncytia formation, including HSV-1, HIV, MeV, SARS-CoV-2, and pneumoviruses
  • Syncytia formation by SARS-CoV-2-infected cells - PubMed
    Here, we show that SARS-CoV-2-infected cells express the Spike protein (S) at their surface and fuse with ACE2-positive neighboring cells Expression of S without any other viral proteins triggers syncytia formation
  • Syncytia formation during SARS-CoV-2 lung infection: a disastrous unity . . .
    Syncytia are evolutionarily conserved cellular structures form by the multiple cell fusions of uninuclear cells In mammals, the best example of physiological syncytia is muscle fibers, which contain thousands of fused muscle cells to allows their rapid coordinated contraction
  • The role of syncytia during viral infections - ScienceDirect
    Respiratory syncytial virus (RSV) is a common, contagious infection of the lungs and the respiratory tract RSV is characterized by syncytia, which are multinuclear cells created by cells that have fused together





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