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  • First-Line Atezolizumab plus Chemotherapy in Extensive-Stage . . .
    Standard-of-care first-line treatment for extensive-stage small-cell lung cancer is platinum chemotherapy (carboplatin or cisplatin) with etoposide 1-3 Despite response rates of 60 to 65%
  • FDA approves atezolizumab for extensive-stage small cell lung . . .
    atezolizumab 1200 mg and carboplatin AUC 5 mg mL min on day 1 and etoposide 100 mg m2 intravenously on days 1, 2 and 3 of each 21-day cycle for a maximum of 4 cycles, followed by atezolizumab 1200
  • First-Line Atezolizumab plus Chemotherapy in Extensive-Stage . . .
    The addition of atezolizumab to chemotherapy in the first-line treatment of extensive-stage small-cell lung cancer resulted in significantly longer overall survival and progression-free survival than chemotherapy alone (Funded by F Hoffmann-La Roche Genentech; IMpower133 ClinicalTrials gov number, …
  • Lurbinectedin with atezolizumab maintenance therapy in . . .
    Small-cell lung cancer (SCLC) is one of the most lethal cancers, with patients diagnosed with extensive-stage small-cell lung cancer (ES-SCLC) experiencing a median survival of just 12 months after standard chemoimmunotherapy 1,2 The addition of immune checkpoint inhibitors such as atezolizumab1 or durvalumab2 to platinum-etoposide chemotherapy followed by immune checkpoint inhibitor
  • The Real-World Outcome of First Line Atezolizumab in . . .
    Keywords: Atezolizumab, Real-world, Small cell lung carcinoma Introduction Small cell lung cancer (SCLC) accounts for approximately 10%-15% of all lung cancers and shows rapid progression and poor prognosis relative to non-SCLC [1-3] Etoposide-containing platinum-based chemotherapy has shown high response rates for extensive-stage (ES) SCLC





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