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  • Placental lakes vs lacunae: spot the differences - Jauniaux . . .
    In normal placentation, lakes usually start appearing as soon as maternal blood begins to flow freely within the intervillous space at the end of the first trimester, whereas, in accreta placentation, lacunae develop progressively during the second trimester
  • Placenta and Placental Development - Clinical Relevance
    On day 9, lacunae or spaces form within the syncytiotrophoblast The syncytiotrophoblast also erodes maternal tissues allowing maternal blood from uterine spiral arteries to enter the lacunar network Thus, early uteroplacental circulation is established by the end of week 2
  • Formation of the Placenta
    Within 11 days of fertilization, the trophoblast forms two layers, 1st the cytotrophoblast and 2nd the syncytiotrophoblast, containing lacunae The placenta forms a barrier to permit exchange of nutrients, gases and wastes with only slight mixing of fetal blood with maternal blood
  • Human placenta and trophoblast development: key molecular . . .
    Considering the crucial role of the placenta in pregnancy complications and long-term health, better insights into molecular mechanisms of human implantation and early placental development should advance options for therapeutic treatment of pregnancy pathologies





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