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  • EMDB lt; EMD-42026 - EMBL-EBI
    EMD-42026 - Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, octamer-centered
  • RCSB PDB - 8U8O: Human retinal variant phosphomimetic IMPDH1 (546 . . .
    Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, octamer-centered
  • IMPDH1 inosine monophosphate dehydrogenase 1 [ (human)]
    The protein encoded by this gene acts as a homotetramer to regulate cell growth The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP) This is the rate-limiting step in the de novo synthesis of guanine nucleotides Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10)
  • IMPDH1 - Wikipedia
    3614 23917 Ensembl ENSG00000106348 ENSMUSG00000003500 UniProt P20839 P50096 RefSeq (mRNA) NM_000883 NM_001102605 NM_001142573 NM_001142574 NM_001142575 NM_001142576 NM_001304521 NM_183243 NM_011829 NM_001302933 NM_001302934 RefSeq (protein) NP_000874 NP_001096075 NP_001136045 NP_001136046 NP_001136047 NP_001136048 NP_001291450 NP_899066 NP_001289862 NP_001289863 NP_035959 Location (UCSC) Chr 7
  • IMPDH1 Gene - GeneCards | IMDH1 Protein | IMDH1 Antibody
    IMPDH1 (Inosine Monophosphate Dehydrogenase 1) is a Protein Coding gene Diseases associated with IMPDH1 include Retinitis Pigmentosa 10 and Leber Congenital Amaurosis 11 Among its related pathways are Metabolism of nucleotides and Infectious disease Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding
  • IMPDH1 retinal variants control filament architecture to tune . . .
    Inosine-5′-monophosphate dehydrogenase (IMPDH), a key regulatory enzyme in purine nucleotide biosynthesis, dynamically assembles filaments in response to changes in metabolic demand Humans have
  • IMPDH dysregulation in disease: a mini review - PMC
    (A) Purine biosynthesis pathway (B) IMPDH monomer (6u9o) has a catalytic domain (green) that binds IMP (gold) and NAD + (salmon) in the active site, and a regulatory domain (pink) with three allosteric nucleotide binding sites that bind GTP (dark blue) and ATP (light blue) The monomer is shown in the GTP-bound inhibited state (C) In solution IMPDH is a tetramer, binding of ATP (sites 1 and 2
  • wwPDB: 8U8O
    PDB Entry - 8U8O (Status - Released) Summary information: Title: Human retinal variant phosphomimetic IMPDH1(546)-S477D filament bound by ATP, IMP, and NAD+, octamer


















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