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  • Theories of Aging: An Ever-Evolving Field - PMC
    The challenge for multicellular organisms such as the human organism is that many cell types lose replicative capacity or divide slowly, even though they remain active throughout the lifespan
  • Cellular Theory of Aging | SpringerLink
    Cellular theories of aging propose that human aging is the result of cellular aging, whereby an increasing proportion of cells reach senescence, a terminal stage at which cells will cease to divide This will limit the body's ability to regenerate and to respond to injury or stress
  • Telomerase and telomeres in aging theory and chronographic aging theory . . .
    Human cells can undergo a limited number of cell divisions and eventually reach an indivisible state called replicative senescence, as telomeres get shorter in each cell division The link between aging and cancer is a critical aspect of modern research
  • Theories and Mechanisms of Aging - Ohio State University
    Cellular changes with normal aging include decreased proliferative capacity and potential of specific cells (lymphocytes and fibroblasts) associated with decreased secretion of interleu-kin-2 and diminished expression of T-cell populations that have an altered affinity for this cytokine
  • Aging, Cell Division | Learn Science at Scitable - Nature
    In 1961, cellular aging was first described by Hayflick and Moorhead They showed that human cells in culture do not divide indefinitely but reach a limit (called the Hayflick limit) of
  • Theories of aging Flashcards | Quizlet
    Study with Quizlet and memorize flashcards containing terms like Aging, What is the cellular clock theory?, Genetic theory and more
  • The cell biology of aging - PMC
    Our understanding of cell biological processes involved in regulating aging have been particularly informed by longevity mutants and treatments, such as reduced insulin IGF-1 signaling and dietary restriction, which are critical in determining the distinction between causes of and responses to aging and have revealed a set of downstream targets
  • Theories on Aging – Lifespan Development
    In 1961, Dr Hayflick theorized that the human cell’s ability to divide is limited to approximately 50-times, after which they simply stop dividing (the Hayflick limit theory of aging)


















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