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  • Clinical characteristics of pancreatic and biliary tract . . .
    Lynch syndrome (LS), hereditary nonpolyposis colon cancer (HNPCC), pancreatic cancer, biliary tract cancer, microsatellite instability (MSI) 1 Introduction Lynch syndrome (LS), previously known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominant disorder caused by pathogenic germline variants in one
  • Aspirin for Lynch syndrome: a legacy of prevention - The Lancet
    Lynch syndrome carriers? Most clinical guidelines7,8 recommend that aspirin be considered for Lynch syndrome carriers These updated data, showing that only 24 Lynch syndrome carriers need to be treated with 600 mg day aspirin to prevent one colorectal cancer, should strengthen such recommendations Nonetheless,
  • open access to scientific and medical research Open Access . . .
    or included Lynch syndrome families based on indivi-duals with dMMR MSI tumors in families with a cancer history,8,21 we chose to include two case studies with VUS26,27 and two case studies with clin-ical Lynch syndrome diagnostics, but with unknown germline MMR gene variant 28,29 Lynch syndrome
  • Tumour testing for hereditary bowel cancer
    People with Lynch syndrome have an increased risk of developing bowel cancer and some other cancers Women who have Lynch Syndrome also have an increased chance of developing womb and ovarian cancer What causes Lynch syndrome? Lynch syndrome is caused by a fault in 1 of 5 different genes (hereditary
  • ACG Clinical Guideline: Genetic Testing and Management of . . .
    genetic testing and management of Lynch syndrome, familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP), MUTYH-associated polyposis (MAP), Peutz-Jeghers syndrome, juvenile polyposis syndrome, Cowden syndrome, serrated (hyperplastic) polyposis syndrome, hereditary pancr eatic cancer, and hereditary gastric cancer
  • “Lynch Syndrome”—From Healer to a Vulnerable Patient: A . . .
    patients with possible Lynch syndrome can significantly affect long-term management plans Timely genetic testing is essential to confirm the diagnosis and identify specific Lynch syndrome mutations, which are crucial in risk assess-mentandmanagementstrategies Delayedgenetictestingcan result in prolonged periods without definitive information,
  • Functional Characterization of a Missense Variant of MLH1 . . .
    Research Article Functional Characterization of a Missense Variant of MLH1 Identified in Lynch Syndrome Pedigree Tahir Zaib ,1,2 Chunhui Zhang ,3 Komal Saleem ,1,2 Lidan Xu ,1,2 Qian Qin ,1,2


















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