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  • Epitope-Optimized Influenza Hemagglutinin Nanoparticle Vaccine Provides . . .
    In this study, we report an epitope-optimized nanoparticle (NPs) vaccine that elicits broad cross-reactive immunity against the H9N2 influenza virus Utilizing Epigraph, a computational algorithm, we first designed three globular heads of H9 hemagglutinin (HA1) with optimized epitopes
  • An influenza hemagglutinin stem nanoparticle vaccine induces cross . . .
    Influenza vaccines could be improved by platforms inducing cross-reactive immunity Immunodominance of the influenza hemagglutinin (HA) head in currently licensed vaccines impedes induction of cross-reactive neutralizing stem-directed antibodies A vaccine without the variable HA head domain has the …
  • Single immunization with an influenza hemagglutinin nanoparticle-based . . .
    Vaccination is the most effective strategy to combat influenza Ideally, potent and persistent vaccine effects would be induced with a single vaccine dose Here, we designed a virus-like particle (VLP)-based vaccine presenting multiple copies of the influenza hemagglutinin (HA) from A Puerto Rico 8 …
  • Mosaic nanoparticle display of diverse influenza virus hemagglutinins . . .
    This necessitates new approaches that provide broader protection against influenza Here we designed a vaccine using the hypervariable receptor-binding domain (RBD) of viral hemagglutinin displayed on a nanoparticle (np) able to elicit antibody responses that neutralize H1N1 influenza viruses spanning over 90 years
  • Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem . . .
    We report the structure-guided development of mammalian-cell-expressed candidate vaccine immunogens based on influenza A virus group 2 H3 and H7 HA stem trimers displayed on self-assembling ferritin nanoparticles using an iterative, multipronged approach involving helix stabilization, loop optimization, disulfide bond addition, and side-chain
  • Induction of Cross-Reactive Hemagglutination Inhibiting Antibody and . . .
    Abstract Background: Recurrent reports of suboptimal influenza vaccine effectiveness have renewed calls to develop improved, broadly cross-protective influenza vaccines Here, we evaluated the safety and immunogenicity of a novel, saponin (Matrix-M)-adjuvanted, recombinant hemagglutinin (HA) quadrivalent nanoparticle influenza vaccine (qNIV)
  • Self-Assembling Nanoparticle Hemagglutinin Influenza Vaccines Induce . . .
    Hemagglutinin (HA) is both the dominant epitope and the main target of influenza-neutralizing antibodies Here, we designed a nanoparticle hemagglutinin influenza vaccine to improve the immunogenicity of the influenza vaccine
  • Influenza Hemagglutinin Nanoparticle Vaccine Elicits Broadly . . .
    Influenza vaccine effectiveness varies annually due to the fast evolving seasonal influenza A (H3N2) strain and egg-derived mutations-both of which can cause a mismatch between the vaccine and circulating strains To address these limitations, we have developed a hemagglutinin (HA)-based protein-detergent nanoparticle influenza vaccine (NIV) with a saponin-based Matrix-M™ adjuvant In a


















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