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  • An overview of cyclophosphamide and ifosfamide pharmacology
    Cyclophosphamide and ifosfamide are alkylating agents administered to treat malignant disease They are prodrugs and require activation by hepatic microsomal enzymes before being metabolized to their respective cytotoxic species, phosphoramide mustard and ifosfamide mustard
  • Ifosfamide vs cyclophosphamide in cancer therapy - PubMed
    Although ifosfamide has been substituted for cyclophosphamide in many therapeutic regimens, it has not been proven superior to cyclophosphamide in any cancer Its current use in non-investigational therapy is for metastatic testicular carcinoma and sarcomas
  • Chapter 106: Anticancer Drugs I: Cytotoxic Agents Flashcards
    Cell-cycle phase-specific drugs do not harm "resting" cells A patient on an oncology unit has been receiving ifosfamide [Ifex] for a few days Before administering the next dose, the nurse reviews the patient's laboratory test results Which finding would cause the nurse to hold the dose? Microscopic hematuria
  • Clinical Pharmacology of Cyclophosphamide and Ifosfamide
    The oxazaphosphorine cyclophosphamide (CPA) and ifosfamide (IFO) are two commonly used DNAalkylating agents in cancer chemotherapy This review highlights the pharmacokinetics and pharmacodynamics of the two important agents
  • Comparative Metabolism of Cyclophosphamide and Ifosfamide in the Mouse . . .
    Ifosfamide (IF) and cyclophosphamide (CP) are common chemotherapeutic agents Interestingly, while the two drugs are isomers, only IF treatment is known to cause nephrotoxicity and neurotoxicity Therefore, it was anticipated that a comparison of IF and CP drug metabolites in the mouse would reveal reasons for this selective toxicity
  • Cyclophosphamide Compared With Ifosfamide in Consolidation Treatment of . . .
    The Intergroup Cooperative Ewing Sarcoma Studies (EICESS-92) investigated whether cyclophosphamide could be used instead of ifosfamide in consolidation chemotherapy of standard-risk Ewing sarcoma (< 100 mL localized tumors) 13 Patients received eight courses of consolidation chemotherapy with either ifosfamide 6 g m 2 (VAIA) or
  • Cyclophosphamide vs Ifosfamide Comparison - Drugs. com
    Compare Cyclophosphamide vs Ifosfamide head-to-head with other drugs for uses, ratings, cost, side effects and interactions
  • Cyclophosphamide versus ifosfamide for paediatric and young adult bone . . .
    Alkylating agents, such as cyclophosphamide and ifosfamide, play a major role in the improved survival of children and young adults with bone and soft tissue sarcoma However, there is still controversy as to their comparative anti‐tumour efficacy and possible adverse effects


















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