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  • Malaria and Early African Development: Evidence from the . . .
    We examine the effect of malaria on economic development in Africa over the very long run Using data on the prevalence of the mutation that causes sickle cell disease, we measure the impact of malaria on mortality in Africa prior to the period in which formal data were collected
  • Evolutionary history of sickle-cell mutation: implications . . .
    Resistance afforded by the sickle-cell trait against severe malaria has led to high frequencies of the sickle-cell mutation [HBB; c 20T>A, p Glu6Val; OMIM: 141900 (HBB-β S)] in most parts of Africa High-coverage sequencing and genotype data have now confirmed the single African origin of the sickle-cell gene variant [ HBB ; c 20T>A, p Glu6Val
  • Natural Selection: Uncovering Mechanisms of Evolutionary . . .
    The evolutionary link between sickle-cell trait and malaria resistance showed that humans can and do adapt But are the “bugs” that make us sick evolving as well?
  • A Synthesis of Current Research on The Evolutionary . . .
    Sickle cell disease, resulting from mutations in the hemoglobin gene (HBB), has been found to offer a survival advantage against malaria in individuals who carry the sickle cell trait This review synthesizes key findings from several landmark studies, tracing the global distribution of sickle cell alleles and their evolutionary origins in
  • Evolutionary race: Malaria evolves to evade sickle cell . . .
    Heterozygous individuals (HbAS) develop a mild sickle cell disease but are (in 90% of the cases) protected against severe malaria The study by Band et al (2021) found that severe malaria cases in African children with the HbAS genotype were associated with the Pfsa+ parasite genotypes
  • Evolution: Library: A Mutation Story - PBS
    Doctors noticed that patients who had sickle cell anemia, a serious hereditary blood disease, were more likely to survive malaria, a disease which kills some 1 2 million people every year
  • Evolutionary history of sickle-cell mutation: implications . . .
    Resistance afforded by the sickle-cell trait against severe malaria has led to high frequencies of the sickle-cell mutation [HBB; c 20T>A, p Glu6Val; OMIM: 141900 (HBB-βS)] in most parts of Africa High-coverage sequencing and genotype data have now confirmed the single African origin of the sickle-cell gene variant [HBB; c 20T>A, p Glu6Val


















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