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Endosomal escape of delivered mRNA from endosomal recycling . . .
Acidification of endosomal lumen leads to release of mRNA from LNP and escape from the endosomal lumen into the cytoplasm Escape occurs mainly from small APPL1 + , EEA1 + , and or Rab11 + tubular endosomes
Strategies and mechanisms for endosomal escape of therapeutic . . .
Open questions to be answered include: why are hepatocytes more permissive for in vivo cytosolic delivery than other tissues? Should one aim for maximum endosomal escape or an optimum release at lower level? Which endosomal escape mechanism is most productive and biocompatible?
Linkage between endosomal escape of LNP-mRNA and . . . - Nature
Endosomal escape of LNP-mRNA is dependent on the molar ratio between ionizable lipids and mRNA nucleotides Our results show that fractions of ionizable lipids and mRNA (1:1 molar ratio of hEPO
Proteoid biodynamers for safe mRNA transfection via pH . . .
Here, we report pH-responsive polymeric nanorods made of amino acid-derivatives connected by dynamic covalent bonds called proteoid-biodynamers, as mRNA vectors They show excellent biocompatibility due to the biodegradation, and outstanding transfection
Endosomal Escape: A Critical Challenge in LNP-Mediated . . .
Endosomal escape of lipid nanoparticles (LNPs) is a crucial process in the intracellular delivery of mRNA-based therapies and vaccines After cellular uptake via endocytosis, LNPs must efficiently release their mRNA payload from endosomes into the cytoplasm to ensure proper translation into therapeutic proteins
Controlling Endosomal Escape Using pH-Responsive . . .
This change in endosomal escape behavior suggests particles can induce escape by different pathways The results show that tuning the core component of pHlexi particles can improve the effectiveness of endosomal escape capabilities and thus their ability to act as effective delivery systems