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  • Sensory neurons and circuits mediating itch - Nature
    Nociceptors High-threshold peripheral receptors or sensory neurons that transduce and encode noxious stimuli Pruriceptors Nociceptors that respond to
  • Jaundice associated pruritis: A review of pathophysiology and . . .
    Han et al[19] has demonstrated a group of MrgprA3-positive neurones in the dorsal root ganglion which, when ablated, result in reduction of itch and scratching behaviour The pattern theory argues that itch, as well as other sensation, is generated by receptors and nerves that are not stimulus specific and the signals are decoded centrally[20
  • Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors . . .
    that MrgprA3 is required for CQ responsiveness in mice Furthermore, MrgprA3-expressing neurons respond to histamine and coexpress gastrin-releas-ing peptide, a peptide involved in itch sensation, and MrgprC11 Activation of these neurons with the MrgprC11-specific agonist BAM8-22 induces itch in wild-type but not mutant mice Therefore, Mrgprs
  • Descending Control of Itch Transmission by the Serotonergic . . .
    that acts, in part, via a Mas-related GPCR (MrgprA3) in sensory neurons and GRPR in the spinal cord (Liu et al , 2009; Sun and Chen, 2007) LMX1B is a LIM homeodomain-containing tran-scription factor that is required for the development of all central 5-HT neurons (Ding et al , 2003) We previously generated con-
  • Critical Players and Therapeutic Targets in Chronic Itch
    Citation: Yang, H ; Chen, W ; Zhu, R ; Wang, J ; Meng, J Critical Players and Therapeutic Targets in Chronic Itch Int J Mol Sci 2022, 23, 9935 https: doi org
  • C EBPβ Participates in Nerve Trauma-Induced TLR7 . . . - Springer
    TRPV1, GRP, TRPA1, and MrgprA3 in DRG neurons [11, 12] Natural and synthetic TLR7 ligands are potent adjuvant for rapid action potential and inward current of nocicep-tive neurons in DRG [11] In our previous study, trauma to the PNS resulting from spinal nerve ligation (SNL) signi-cantly increased TLR7 expression in injured DRG neurons
  • Mechanisms of Itch in Atopic Dermatitis - J-STAGE
    NP2 neurons express MrgprA3, MrgprC11, and the histamine H1 receptor NP3 neurons express the IL-31 receptor, serotonin receptors, histamine H1 receptor, and leukotriene C4 receptors All three clusters, NP1, NP2, and NP3, commonly express IL-4 and IL-13 receptors20, 21) However, it remains unclear which subsets of neurons are increased in


















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