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  • Tooele Army Depot | US Army
    Sitting at the junction of major east-west and north-south rail and highway transportation corridors and near international airfields, TEAD is the Gateway to the Pacific and equidistant from
  • Targeting TEAD in cancer - Frontiers
    The transcription factor TEAD plays a critical role in early development, tissue homeostasis, and cell proliferation, and it binds to the downstream Hippo pathway co-activators YAP and TAZ Numerous studies have examined the roles of YAP TAZ and TEAD in cancer, with their activity frequently linked to poor clinical prognosis
  • Therapeutic targeting of TEAD transcription factors in cancer
    Three small molecule TEAD inhibitors are currently being tested in Phase I clinical trials In this review, we highlight the role of TEADs in cancer, discuss various avenues through which TEAD activity can be inhibited, and outline the opportunities for the administration of TEAD inhibitors
  • Regulation of TEAD Transcription Factors in Cancer Biology
    Transcriptional enhanced associate domain (TEAD) transcription factors play important roles during development, cell proliferation, regeneration, and tissue homeostasis
  • Teads (TEAD) Stock Price, News Analysis - MarketBeat
    Should You Buy or Sell Teads Stock? Get The Latest TEAD Stock Analysis, Price Target, Earnings Estimates, Headlines, and Short Interest at MarketBeat
  • A Fragment Screen Identifies Acrylamide Covalent Inhibitors of the TEAD . . .
    TEA domain (TEAD) proteins bind co-activator Yes-associated protein (YAP) to regulate the expression of target genes of the Hippo pathway The TEAD-YAP protein-protein interaction is not druggable, but TEADs possess a unique and deep palmitate pocket with a highly conserved cysteine located outside the TEAD-YAP protein-protein interaction interface Here, we screen a fragment library of
  • TEAD-targeting small molecules induce a cofactor switch to . . . - PNAS
    TEAD proteins are the main transcriptional effectors of the Hippo signaling pathway and a clinical-stage pharmacological target in oncology Most TEAD-targeting small molecules are designed to disr
  • Pharmacological blockade of TEAD–YAP reveals its therapeutic . . . - Nature
    Here we show that TEAD palmitoylation inhibitor MGH-CP1 and analogues block cancer cell “stemness”, organ overgrowth and tumor initiation in vitro and in vivo





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