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  • 16. 3: Erythrocytes - Medicine LibreTexts
    Hemoglobin is a large molecule made up of proteins and iron It consists of four folded chains of a protein called globin , designated alpha chain 1 and 2, and beta chain 1 and 2 Each of these globin molecules is bound to a red pigment molecule called heme , which contains an ion of iron (Fe 2+ ) (Figure \(\PageIndex{3}\))
  • 8. 8: Erythrocytes - Medicine LibreTexts
    Hemoglobin that is not phagocytized undergoes breakdown in the circulation, with the alpha and beta chains being released and subsequently removed from circulation by the kidneys 6 Figure 6 | Erythrocyte Lifecycle and Hemoglobin Recycling | 9 This figure illustrates the lifecycle of red blood cells (erythrocytes), from their production in the bone marrow to their breakdown and recycling of
  • 7. 4: Hemoglobin C (Hb CC) Disease - Medicine LibreTexts
    This page titled 7 4: Hemoglobin C (Hb CC) Disease is shared under a CC BY-NC 4 0 license and was authored, remixed, and or curated by Valentin Villatoro and Michelle To (Open Education Alberta) via source content that was edited to the style and standards of the LibreTexts platform
  • 21. 9C: Oxygen Transport - Medicine LibreTexts
    Hemoglobin About 98 5% of the oxygen in a sample of arterial blood in a healthy human breathing air at sea-level pressure is bound to the hemoglobin in blood (Hgb) Hemoglobin is a protein found in red blood cells (also called erythrocytes) There are roughly 270 million hemoglobin molecules in a single red blood cell, and each contains 4 heme
  • 5. 1D: Skin Color - Medicine LibreTexts
    Hemoglobin is the iron-containing protein pigment of our blood cells A lack of oxygen saturation imparts a paler, grayer, or bluer color to the skin Skin may also become paler as a result of anemia (a reduced number of hemoglobin and or red blood cells), low blood pressure, or poor circulation of blood
  • 18. 4: Erythrocytes - Medicine LibreTexts
    Hemoglobin that is not phagocytized is broken down in the circulation, releasing alpha and beta chains that are removed from circulation by the kidneys The iron contained in the heme portion of hemoglobin may be stored in the liver or spleen, primarily in the form of ferritin or hemosiderin, or carried through the bloodstream by transferrin to the red bone marrow for recycling into new
  • 16. 2B: RBC Physiology - Medicine LibreTexts
    The word hemoglobin comes from “hemo” meaning blood and “globin” meaning protein Hemoglobin is a quaternary structure protein consisting of many smaller tertiary structure proteins composed of amino acid polypeptide chains Each hemoglobin molecule contains four iron-binding heme groups, which are the site of oxygen (O 2) binding
  • 16. 2: CO₂ Transport - Medicine LibreTexts
    Hemoglobin then serves yet another purpose by buffering the proton with its polypeptide chains Deoxyhemoglobin is a better proton acceptor than oxyhemoglobin, so as the hemoglobin loses its oxygen at the tissue it becomes a better pH buffer





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