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  • PRAME - Wikipedia
    PRAME (preferentially expressed antigen of melanoma) is a protein that in humans is encoded by the PRAME gene [3][4][5] Five alternatively spliced transcript variants encoding the same protein have been observed for this gene
  • PRAME Expression in Melanocytic Tumors - PMC
    PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells in a melanoma patient While frequent PRAME mRNA expression is well documented in cutaneous and ocular melanomas, little is
  • PRAME Expression in Melanocytic Tumors - PubMed
    In this study we examined the immunohistochemical expression of PRAME in 400 melanocytic tumors, including 155 primary and 100 metastatic melanomas, and 145 melanocytic nevi Diffuse nuclear immunoreactivity for PRAME was found in 87% of metastatic and 83 2% of primary melanomas
  • PRAME Gene - GeneCards | PRAME Protein | PRAME Antibody
    PRAME (PRAME Nuclear Receptor Transcriptional Regulator) is a Protein Coding gene Diseases associated with PRAME include Retinal Melanoma and Conjunctival Nevus
  • PRAME – MyPathologyReport
    PRAME stands for “preferentially expressed antigen in melanoma ” It is a special type of protein called a cancer-testis antigen This means that PRAME is usually found in cancer cells and normal cells within the testis, but rarely in other normal tissues of the body
  • The Role of PRAME in Malignant Melanoma: From Biomarker to Therapeutic . . .
    PRAME emerges as a promising biomarker and therapeutic target in malignant melanoma, offering avenues for improved diagnosis, prognostication, and treatment Its pivotal roles in driving disease progression underscore its significance in malignant melanoma pathogenesis
  • Tumor-associated antigen Prame targets tumor suppressor p14 ARF for . . .
    Protein Preferentially Expressed Antigen in Melanoma (Prame), a tumor-associated antigen, has been found to frequently overexpress in various cancers, which indicates advanced cancer stages
  • PRAME Expression in Cancer. A Systematic Immunohistochemical Study of . . .
    Preferentially expressed antigen in melanoma (PRAME) is considered a useful marker in the differential diagnosis between malignant melanoma and its melanocytic mimics Recently PRAME expression was documented in nonmelanocytic tumors, but much of the data are based on mRNA studies
  • How Useful Is PRAME Testing in Choroidal Melanoma?
    Preferentially expressed antigen in melanoma, or PRAME, is a cancer-test antigen that is overexpressed in melanoma and is typically a marker of poor outcomes Up first, Zélia M Corrêa, MD, PhD, explained why she favors testing for PRAME Improved prognostic testing accuracy
  • The role of the cancer testis antigen PRAME in tumorigenesis and . . .
    Preferentially expressed antigen in melanoma (PRAME), which belongs to the cancer testis antigen (CTA) gene family, plays a pivotal role in multiple cellular processes and immunotherapy response in human cancers





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