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  • Understanding Your Positive MITF Genetic Test Result
    There are options to detect cancer early or lower the risk to develop cancer It is important to discuss these options with your doctor and decide on a plan that works for you Family members may also be at risk – they can be tested for the MITF mutation that was found in you
  • MITF Gene - GeneCards | MITF Protein | MITF Antibody
    MITF (Melanocyte Inducing Transcription Factor) is a Protein Coding gene Diseases associated with MITF include Tietz Albinism-Deafness Syndrome and Waardenburg Syndrome, Type 2A Among its related pathways are MITF-M-dependent gene expression and Transport of the SLBP independent Mature mRNA
  • Emerging roles of MITF as a crucial regulator of immunity
    Microphthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper transcription factor (bHLH-Zip), has been identified as a
  • MITF gene - Myriad Genetics
    The following information for Family Members will appear as part of the MMT for a patient found to have a mutation in the MITF€gene This patient's relatives are at risk for carrying the same mutation(s) and associated cancer risks as this patient
  • Microphthalmia-associated transcription factor - Wikipedia
    Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the MITF gene
  • About Mutations in the MITF Gene - Memorial Sloan Kettering Cancer Center
    A MITF mutation increases your risk of skin cancer and kidney cancer While a MITF mutation means you have a somewhat higher risk of developing cancer than the average person, it may not fully explain why your blood relatives have cancer
  • Microphthalmia-Associated Transcription Factor (MITF): Multiplicity in . . .
    Microphthalmia-associated transcription factor (MITF) regulates the differentiation and development of melanocytes and retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes Hetero zygous mutations in the MITF gene cause auditory–pigmentary syndromes
  • About Mutations in the MITF Gene - Memorial Sloan Kettering Cancer Center
    What is my cancer risk if I have a MITF mutation? A MITF mutation increases your risk of skin cancer and kidney cancer While a MITF mutation means you have a somewhat higher risk of developing cancer than the average person, it may not fully explain why your blood relatives have cancer
  • MITF in Normal Melanocytes, Cutaneous and Uveal Melanoma: A Delicate . . .
    Microphthalmia-associated transcription factor (MITF) is an important regulator of melanogenesis and melanocyte development Although it has been studied extensively in cutaneous melanoma, the role of MITF in uveal melanoma (UM) has not been explored in much detail
  • Multiple Injury Trust Fund - Oklahoma. gov
    The Multiple Injury Trust Fund (MITF) is a creature of statute (85 O S and 85A O S ) which pays permanent total disability benefits as ordered by the Oklahoma Court of Existing Claims and Oklahoma Worker’s Compensation Commission MITF pays 90% of Oklahoma’s permanent disability
  • MITF has a central role in regulating starvation-induced . . . - Nature
    Here we show that MITF binds the CLEAR-box element in the promoters of lysosomal and autophagosomal genes in melanocytes and melanoma cells The crystal structure of MITF bound to the CLEAR-box
  • Cancer risks associated with the germline MITF(E318K) variant
    The MITF(E318K) variant confers moderate risk for cutaneous melanoma While there are small studies suggesting that this risk is associated with other malignancies (e g renal cell carcinoma), little is known about the role of this variant in specifying risk for other cancers
  • MITF the first 25 years - Genes Development
    In the 25 yr since the gene encod-ing the microphthalmia-associated transcription factor (MITF) was first isolated, MITF has emerged as a key co-ordinator of many aspects of melanocyte and melanoma biology Like all transcription factors, MITF binds to spe-cific DNA sequences and up-regulates or down-regulates its target genes





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