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  • Functional and structural basis of extreme conservation in . . .
    The lack of knowledge about extreme conservation in genomes remains a major gap in our understanding of the evolution of gene regulation Here, we reveal an unexpected role of extremely conserved 5' untranslated regions (UTRs) in noncanonical translational regulation that is linked to the emergence …
  • The Genome 10K Project: A Way Forward | Annual Reviews
    The Genome 10K Project was established in 2009 by a consortium of biologists and genome scientists determined to facilitate the sequencing and analysis of the complete genomes of 10,000 vertebrate species Since then the number of selected and initiated species has risen from ∼26 to 277 sequenced or ongoing with funding, an approximately tenfold increase in five years Here we summarize the
  • De-extinction: digital lab tech supports a mammoth project
    In July 2022, Colossal and the Vertebrate Genomes Project announced they had successfully sequenced and assembled the Asian elephant genome at reference-genome level, the first of its kind for
  • The evolution of isochore patterns in vertebrate genomes
    Background: Previous work from our laboratory showed that (i) vertebrate genomes are mosaics of isochores, typically megabase-size DNA segments that are fairly homogeneous in base composition; (ii) isochores belong to a small number of families (five in the human genome) characterized by different GC levels; (iii) isochore family patterns are different in fishes amphibians and mammals birds
  • Scalable multiple whole-genome alignment and locally . . . - Nature
    With ongoing initiatives like the Vertebrate Genomes Project and the insect5k, thousands of species will soon have a reference genome available, and the sequencing and assembly of various
  • Whole-Genome Duplications and the Diversification of the . . .
    Rhie A, et al 2021 Towards complete and error-free genome assemblies of all vertebrate species Nature 592(7856):737–746 [PMC free article] [Google Scholar] Roesner A, Fuchs C, Hankeln T, Burmester T 2005 A globin gene of ancient evolutionary origin in lower vertebrates: evidence for two distinct globin families in animals
  • Diversity, function and evolution of aquatic vertebrate genomes
    Aquatic vertebrates consist of jawed fish (cartilaginous fish and bony fish), aquatic mammals, reptiles and amphibians Here, we present a comprehensive analysis of 630 aquatic vertebrate genomes to generate a standardized compendium of genomic data We demonstrate its value by assessing their genome features as well as illuminating gene families related to the transition from water to land





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