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  • Simultaneous subset tracing and miRNA profiling of tumor-derived . . .
    Here, we develop a precise and robust one-pot assay called dual-surface-protein-guided orthogonal recognition of tumor-derived exosomes and in situ profiling of microRNAs (SORTER) to detect tumor-derived exosomal miRNAs and enhance the diagnostic accuracy of prostate cancer (PCa)
  • SORTER – simultaneous subset tracing and miRNA profiling of tumor . . .
    The SORTER assay is designed to achieve specific recognition and sorting of tumor-derived exosome subtypes and in situ sensitive probing of tumor-derived exosomal miRNA profiles (III) Data processing and bioinformatic analysis for cancer diagnosis
  • Simultaneous subset tracing and miRNA profiling of tumor-derived . . .
    Here, we develop a precise and robust one-pot assay called dual-surface-protein-guided orthogonal recognition of tumor-derived exosomes and in situ profiling of microRNAs (SORTER) to detect tumor-derived exosomal miRNAs and enhance the diagnostic accuracy of prostate cancer (PCa)
  • Simultaneous subset tracing and miRNA proling of tumor-derived exosomes . . .
    Here we developed a one-pot assay called dual-Surface-protein-guided 18 Orthogonal Recognition of Tumor-derived Exosomes and in-situ profiling of microRNAs (SORTER) for 19 rapid and
  • 分子医学研究院杨朝勇团队在Science Advances发表成果：开发肿瘤外泌体miRNA液体活检新方法
    近日，上海交通大学医学院分子医学研究院杨朝勇团队在Science Advances杂志（IF= 13 6）发表了题目为“Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding”的研究工作。 该工作报道了一种精确且稳健的一锅法（SORTER），用于临床血浆样本中肿瘤外泌体的亚群追踪及其miRNA原位分型。 （图：基于SORTER的肿瘤外泌体亚群追踪及其miRNA原位检测示意图）
  • 我国科学家通过双表面蛋白正交标记实现肿瘤来源的外泌体识别及其miRNA的原位分析 - 知乎
    来自厦门大学及 上海交通大学医学院附属仁济医院 泌尿外科分子医学研究所的科学家团队在《Science Advances》期刊上发表题为“Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding”相关研究论文。 该研究表明通过双 表面蛋白 引导的肿瘤源性外泌体正交识别和 microRNA 原位分析 (SORTER)，以标记未提取血浆中的肿瘤源性外泌体 miRNA 并提高了前列腺癌的诊断准确性。 SORTER技术在评估肿瘤来源的外泌体miRNA谱时表现出快速、无创、避免分离、可扩展性和高精度的独特优势。
  • Boosting selective fusion of protocells with DNA logic circuits for
    Our results demonstrate that leveraging DNA logic circuits to boost selective fusion of protocells enables direct detection of tumor-derived exosomal miRNAs in cell culture medium and plasma, displaying 100% accuracy in clinical sample analysis
  • Simultaneous subset tracing and miRNA profiling of tumor-derived . . .
    With a signature of six miRNAs, SORTER differentiated prostate cancer and benign prostatic hyperplasia with a sensitivity, specificity, and accuracy of 100% in the training and validation cohorts The SORTER provides a promising tool to advance the clinical adaptability of miRNA-based liquid biopsy
  • Supplementary Materials for - Science | AAAS
    Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding Yanmei Lei et al Corresponding author: Ying Zhuo, yingzhuo@swu edu cn; Wei Xue, xuewei@renji com; Peng Zhang, pengzhang016@sjtu edu cn; Chaoyong Yang, cyyang@xmu edu cn Sci Adv 9, eadi1556 (2023) DOI: 10 1126 sciadv adi1556
  • 分子医学研究院杨朝勇团队在Science Advances发表成果：开发肿瘤外泌体miRNA液体活检新方法
    近日，上海交通大学医学院分子医学研究院杨朝勇团队在Science Advances杂志（IF= 13 6）发表了题目为“Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding”的研究工作。 该工作报道了一种精确且稳健的一锅法（SORTER），用于临床血浆样本中肿瘤外泌体的亚群追踪及其miRNA原位分型。 MicroRNA (miRNA)是一类短的非编码单链RNA（约22个核苷酸），通过翻译抑制、靶基因降解和基因沉默在转录后水平调控基因的表达。 外泌体是一种通过多囊泡体途径产生的纳米级细胞外囊泡。





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