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  • Sickle Cell Disease - What Is Sickle Cell Disease? | NHLBI, NIH
    Sickle cell disease — also called sickle cell anemia — is a group of inherited disorders that affect hemoglobin , the major protein that carries oxygen in red blood cells Normally, red blood cells are disc-shaped and flexible so they can move easily through the blood vessels
  • Sickle Cell Disease - Causes and Risk Factors | NHLBI, NIH
    Who can get sickle cell disease? Sickle cell disease is a genetic disorder caused by mutations in hemoglobin genes, leading to a faulty hemoglobin protein, called hemoglobin S Hemoglobin S changes flexible red blood cells into rigid, sickle-shaped cells The sickled cells can block blood flow and cause pain and organ damage
  • How Sickle Cell Disease May Affect Your Health - NHLBI, NIH
    Sickle cell disease can cause pain, infections, and joint problems throughout the body It can also lead to severe anemia and complications in specific body parts
  • Anemia - What Is Anemia? | NHLBI, NIH
    Anemia is a common condition that occurs when your blood has a lower-than-normal amount of red blood cells or hemoglobin Anemia can be inherited or acquired Learn about the causes, symptoms, and treatments for anemia
  • Pregnancy, Reproduction, and Sickle Cell Disease - NHLBI, NIH
    Sickle cell disease can affect sexual organs and other parts of the body in ways that affect quality of life and reproduction Pregnancy puts extra stress on a woman’s body, raising the risk of sickle cell complications Having sickle cell disease also raises the risk of problems with the pregnancy and with the developing baby
  • Sickle Cell Disease - Sickle Cell Trait | NHLBI, NIH
    People with sickle cell trait carry only one copy of the sickle hemoglobin gene and rarely have any symptoms of sickle cell disease However, in rare instances, some people who have sickle cell trait can experience medical complications
  • Sickle Cell Disease Milestones in Research and Clinical Progress
    The National Sickle Cell Anemia Control Act provides for the establishment of voluntary sickle cell disease screening, patient counseling, public and professional education, and research and training in diagnosing, treating, and controlling the disease
  • Sickle Cell Disease - Symptoms | NHLBI, NIH
    Serious pain linked with sickle cell disease often requires treatment in a clinic or hospital Fatigue (extreme tiredness), shortness of breath, dizziness, and irregular heartbeat These are symptoms of serious anemia Life-threatening anemia can be caused by conditions such as a splenic sequestration crisis crisis or an aplastic crisis Fever
  • Evidence-Based Management of Sickle Cell Disease: Expert Panel, 2014
    The purpose of the “Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014” is to synthesize the available scientific evidence on sickle cell disease and offer guidance to busy primary care clinicians
  • Sickle Cell Disease - Treatment | NHLBI, NIH
    Treatment options for sickle cell disease include medicines that lessen symptoms, blood transfusions, blood and bone marrow transplants, and gene therapy treatments Bone marrow transplants and gene therapies are potential cures for some people





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