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  • Pharmacokinetics of Ertapenem following Intravenous and Subcutaneous . . .
    Steady-state pharmacokinetics of ertapenem were compared in patients after 1-g intravenous and subcutaneous (s c ) infusions Bioavailability was 99% ± 18% after s c administration, but peaks were reduced by about (43 ± 29 versus 115 ± 28 μg ml) and times to peak were delayed
  • Pharmacokinetics of intramuscularly administered ertapenem
    The plasma pharmacokinetics of a 1-g intramuscular (i m ) dose was compared with those of a 1-g intravenous (i v ) dose infused over 30 min, the recommended rate of i v infusion for comparison, and over 120 min, which more closely mimicked the time course for absorption of the i m form
  • Pharmacokinetics of Ertapenem in Healthy Young Volunteers
    The objectives of this study were to (i) assess the dose proportionality of intravenous (i v ) doses of ertapenem across the dose range of 0 5 to 3 g, (ii) evaluate the plasma protein binding of ertapenem in vivo, (iii) compare the pharmacokinetic parameters of ertapenem across studies following the proposed therapeutic dose of 1 g i v
  • Ertapenem | Daviss Drug Guide for Rehabilitation Professionals | F. A . . .
    Pharmacokinetics Absorption: 90% after IM administration; IV administration results in complete bioavailability Distribution: Enters breast milk Metabolism and Excretion: Mostly excreted by the kidneys Half-life: 1 8 hr (increased in renal impairment)
  • Ertapenem Monograph for Professionals - Drugs. com
    Following IM injection, mean bioavailability is approximately 90%; peak plasma concentrations attained in approximately 2 3 hours Exhibits nonlinear pharmacokinetics because of concentration-dependent plasma protein binding
  • Pharmacokinetics of Ertapenem following Intravenous and Subcutaneous . . .
    Steady-state pharmacokinetics of ertapenem were compared in patients after 1-g intravenous and subcutaneous (s c ) infusions Bioavailability was 99% ± 18% after s c administration, but peaks were reduced by about (43 ± 29 versus 115 ± 28 μg ml) and times to peak were delayed
  • C:\Data\My Documents\N21337 AP Letter. doc
    Absorption Ertapenem, reconstituted with 1% lidocaine HCl injection, USP (in saline without epinephrine), is almost completely absorbed following intramuscular (IM) administration at the
  • Population pharmacokinetics and probability of target attainment of . . .
    Our results indicate that 1 g of ertapenem administered twice daily, by the iv or sc route, may optimize ertapenem exposure and achievement of PK PD targets in patients with BJI Ertapenem is a therapeutic option for the treatment of bone and joint infection (BJI)
  • Comparative pharmacokinetics, pharmacodynamics, and tolerability of . . .
    Ertapenem administered as a rapid 5-minute infusion provides a well tolerated, bioequivalent, and pharmacodynamically equivalent regimen to the 30-minute infusion at clinically relevant MICs
  • Subcutaneous Antibiotic Therapy: The Why, How, Which Drugs and When
    Frasca et al reported that SC administration resulted in a lower Cmax compared with IV administration, but the AUCs over the dosing interval were similar, which suggests a bioavailability close to 100% 40 Similar findings have been reported for high-dose ertapenem in bone and joint infections (BJIs)41,61 Population PK PD parameters and the





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