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  • TGF-β signaling and its targeting for glioma treatment - PMC
    TGF-β signaling is dysregulated in cancer patients, and this aberrant signaling at least in part contributes to initiation and progression of many cancers including glioma The dysregulated signaling components provide molecular targets for the treatment of glioma In this article, we review TGF-β signaling and its targeting in glioma
  • TGF-β as a therapeutic target in high grade gliomas - ScienceDirect
    Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines
  • 227 Targeting TGFβ pathway to enhance CAR-T therapy for glioblastoma
    Using our syngeneic glioma model, we evaluated the importance of inhibiting the TGFβ pathway We demonstrated that pretreatment with a TGFβR1 inhibitor (LY3200882) significantly augmented the efficacy of CAR-T therapy and improved overall survival of mice bearing large established tumors
  • New advances in cancer therapy targeting TGF-β signaling pathways
    Secretion of transforming growth factor β (TGF-β) is a prominent feature of cancer development and a striking way to inhibit anti-tumor immunity Elimination effects of TGF-β have far-reaching positive implications for future immunotherapy
  • Molecular Pathways: Targeting the TGF-β Pathway for Cancer Therapy
    The 3 main approaches to inhibiting TGF-β or its pathway components include (i) antisense oligonucleotides (ASO) delivered directly into the tumor or engineered into immune cells; (ii) TGF-β–neutralizing antibodies which block access of TGF-β ligand to its receptor; and (iii) TGF-β receptor kinase inhibitors The greatest challenge for
  • The TGF-β Family in Glioblastoma - PMC - PubMed Central (PMC)
    TGF-βs signaling promotes tumorigenesis in glioblastoma, while BMPs suppress tumorigenic potential by inducing tumor cell differentiation In this review, we discuss the actions of TGF-βs and BMPs on cancer cells as well as in the tumor microenvironment, and their use in potential therapeutic intervention Keywords: TGF-β, BMP, glioblastoma 1
  • A novel approach to enhance glioblastoma multiforme treatment efficacy . . .
    This review focuses on how these molecular insights can serve as novel therapeutic targets and how drug adjuvant therapy may improve GBM treatment strategies by releasing immunosuppressive mediators (such as TGF-β, IL-10, and PGE-2) biomarkers c-myc, cyclin D1, and fra-1 mRNA and protein in glioma cells lines: U87 and A172 by





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