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  • Pan-cancer T cell atlas links a cellular stress response state to . . .
    We identified a unique stress response state, T STR, characterized by heat shock gene expression T STR cells are detectable in situ in the tumor microenvironment across various cancer types, mostly within lymphocyte aggregates or potential tertiary lymphoid structures in tumor beds or surrounding tumor edges
  • Pan-cancer T cell atlas links a cellular stress response state to . . .
    We identified a unique stress response state, T STR, characterized by heat shock gene expression T STR cells are detectable in situ in the tumor microenvironment across various
  • Nature Medicine重大突破：T细胞又现新状态！ - 知乎专栏
    近日，德克萨斯大学MD安德森癌症中心 的研究团队发表在 《Nature Medicine》 （IF: 87 241）上的一项新研究“Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance”对T细胞状态的广泛多样性以及它们在复杂的肿瘤微环境中的
  • Nature Medicine：王淩华实验室绘制泛癌T细胞图谱，利用大 . . .
    2023年5月29日，德州大学MD安德森癌症中心王凌华博士和她的团队（初砚硕博士为论文第一作者）在 Nature Medicine 期刊发表了题为：Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance 的研究论文。
  • 迄今最全“泛癌T细胞”图谱问世，最新研究揭秘肿瘤微环境新 . . .
    5月29日，由德克萨斯大学MD安德森癌症中心的研究人员领导的一项新研究“Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance”发表在《Nature Medicine》上，对T细胞状态的广泛多样性以及它们在复杂的肿瘤微环境中的
  • Pan-cancer T cells图谱揭示细胞应激状态与免疫treat抗性的关联
    2023年5月29号，《Nature Medicine》（影响因子：82 9）发布了一个题为《Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance》的研究论文 [1]。 tumor浸润T细胞（TILs）是cancer免疫微环境的重要组成部分，并在多种免疫疗法中显示出anticancer效果。 然而，TILs的表型和功能多样，且影响anticancer疗法的效果。 尽管已有研究开始揭示TILs的状态和通往耗竭的路径，但对它们的进一步深入理解对于有效分层患者和推进未来疗法至关重要。 此外，由于缺乏统一的标记和基因特征来定义TIL状态，跨研究比较存在挑战。
  • 遇强则强，实力不详！生信大牛王凌华再发 Cancer Cell！这 . . .
    2025年3月，王凌华团队在Cancer Cell 杂志发表题为Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics的研究论文，运用单细胞空间转录组技术，首次绘制出CAFs的“三维作战地图”。
  • Pan-cancer T cell atlas reveals new details of tumor microenvironment
    High-resolution spatial profiling image showing stressed T cells within the tumor microenvironment In the image, tumor cells are shown in tan, fibroblasts in yellow, and T cells in wine color T cells in stress response state are marked with white dots
  • Pan-cancer T cell atlas links a cellular stress response state to . . .
    We identified a unique stress response state, TSTR, characterized by heat shock gene expression TSTR cells are detectable in situ in the tumor microenvironment across various cancer types, mostly within lymphocyte aggregates or potential tertiary lymphoid structures in tumor beds or surrounding tumor edges
  • Pan-Cancer T Cell Atlas Links a Cellular Stress Response State to . . .
    We identified a unique stress response state, TSTR, characterized by heat shock gene expression TSTR cells are detectable in situ in the tumor microenvironment across various cancer types, mostly within lymphocyte aggregates or potential tertiary lymphoid structures in tumor beds or surrounding tumor edges





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