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  • ECM alterations in Fndc3a (Fibronectin Domain Containing . . .
    Both genes share highest sequence similarities with FNDC3B and form a distinct subgroup aside from FNDC3A gens Amino acid alignment comparison of both zebrafish paralogous to human FNDC3B show for Fndc3ba up to 68%% amino acid identity by 98% coverage, while Fndc3bb shows up to 56% by 98% coverage
  • Expression Analysis of Fibronectin Type III Domain-Containing . . .
    FNDC3B, the second member of the FNDC3 subfamily, shares 50% amino acid identity with FNDC3A It is known that FNDC3B is highly amplified in esophageal, lung, ovarian, and breast cancer and it has been associated with the activation of several cancer pathways including PI3-kinase Akt, Rb1, and TGF-β signaling
  • Overexpression of fibronectin type III domain containing 3B . . .
    Fibronectin (FN) type III domain containing 3B (FNDC3B), a member of the FN family, regulates the invasion and metastasis of cells in numerous tumor types However, the mechanisms through which FNDC3B regulates carcinogenesis in lung adenocarcinoma (LADC) tissues have remained elusive The present s …
  • ECM alterations in Fndc3a (Fibronectin Domain Containing . . .
    We established a hypomorphic fndc3a mutant line (fndc3awue1 wue1) via CRISPR Cas9, exhibiting phenotypic malformations and changed gene expression patterns during early stages of median n fold
  • Identification of fibronectin type III domain containing 3B . . .
    Based on statistical ranking, FNDC3B expression above or below the median value was categorized as FNDC3B-high or FNDC3B-low groups Identification of differential expression genes (DEGs) Using DESeq2 (v1 26 0), we leveraged TCGA database to discern DEGs between the FNDC3B-high and FNDC3B-low groups
  • ECM alterations in Fndc3a (Fibronectin Domain Containing . . .
    Both genes share highest sequence similarities with FNDC3B and form a distinct subgroup aside from FNDC3A gens Amino acid alignment comparison of both zebrafish paralogous to human FNDC3B show for Fndc3ba up to 68%% amino acid identity by 98% coverage, while Fndc3bb shows up to 56% by 98% coverage





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