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  • Optimising cell-based bioassays via integrated design of . . .
    We therefore introduce the integrated DoE (ixDoE) approach to target a smarter use of DoEs in the bioassay setting, specifically in optimising resources and time Where in a standard practice 3 to 4 separate DoEs would be performed, our ixDoE approach includes the necessary statistical inference from only a single experimental set
  • CD11a (LFA-1) (HI111) - BD Biosciences
    Antibody titration is critical for successful post-permeabilization staining of CD markers and other cell surface antigens The 1X concentration represents cells stained with the recommended test size for live cell stains
  • Inhibition of Protein-Protein Interactions: Cell-Based Assays
    There is a strong interest in discovering compounds that inhibit protein-protein interactions High-throughput screening (HTS) approaches include formats using purified proteins (see AGM chapter Inhibition of Protein-Protein Interactions: Non-Cellular Assay Formats) (1) and those using whole cells
  • Functional selection of protease inhibitory antibodies - PNAS
    Using this method to select from synthetic human antibody libraries, we isolated panels of mAbs inhibiting 5 targets of 4 main protease classes: matrix metalloproteinases (MMP-14, a predominant target in metastasis; MMP-9, in neuropathic pain), β-secretase 1 (BACE-1, an aspartic protease in Alzheimer’s disease), cathepsin B (a cysteine protease
  • Brilliant Violet 510™ anti-human CD11a Antibody - BioLegend
    HI111 is specific for the closed confirmation of the integrin 8 Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections, Western blotting 2 , and blocking of cell-cell interaction and inhibition the binding of ICAM-1 4
  • CD11a (LFA-1alpha) Monoclonal Antibody (HI111), Functional . . .
    Invitrogen Anti-CD11a (LFA-1alpha) Monoclonal (HI111), eBioscience™, Catalog # 16-0119-81 Tested in Flow Cytometry (Flow), Neutralization (Neu) and Functional Assay (Functional) applications This antibody reacts with Human samples Supplied as 50 µg purified antibody (1 mg mL)





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