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  • Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of . . .
    As a direct consequence of their significant physiological and toxicological roles, inhibitors of the ALDH enzymes have been developed to treat human diseases This review summarizes known ALDH inhibitors, their mechanisms of action, isozyme selectivity, potency, and clinical uses
  • Aldehyde Dehydrogenase Inhibitor - ScienceDirect
    Another criterion for classifying ALDH inhibitors is based on the isozymes they target and whether they are specific AMPAL targets ALDH1 and ALDH3, which are frequently high in cancer cells Whereas, Benomyl (methyl- [1- [ (butylamino)carbonyl]-1H-benzimidazol-2-yl]carbamate) inhibit only ALDH2 isozyme
  • Discovery of Selective Aldehyde Dehydrogenase Inhibitors for . . .
    ALDH overexpression is closely related to resistance in therapies and to cancer stem cells’ self-renewal, differentiation, and protection against oxidative stress Consequently, targeting these enzymes might represent a new potential strategy to overcome therapeutic resistance in cancer patients
  • Aldehyde dehydrogenase inhibitors: a comprehensive review of . . .
    As a direct consequence of their significant physiological and toxicological roles, inhibitors of the ALDH enzymes have been developed to treat human diseases This review summarizes known ALDH inhibitors, their mechanisms of action, isozyme selectivity, potency, and clinical uses
  • Human Aldehyde Dehydrogenases: A Superfamily of Similar Yet . . .
    CVT-10216 is a very effective reversible inhibitor of mitochondrial ALDH2 (IC50 of 29 nM) and ALDH423 is another ALDH2 specific inhibitor found through a target-specific rescoring technique (IC50 of 0 62 μM)
  • Emerging Roles of Aldehyde Dehydrogenase Isoforms in Anti . . .
    Dissecting the role of ALDH specific isoforms in the TME can open new scenarios in the cancer treatment In this review, we summarize the current knowledge about the role of ALDH isoforms in solid tumors, in particular in association with therapy-resistance





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